A Ciliary Phosphoinositide Pathway Regulates the Dosage of Polycystins in Primary Cilia
Our results demonstrated that increasing the ciliary level of PCs, by manipulating a ciliary phosphoinositide signaling axis, enhanced the functionality of PCs and suppressed cystogenesis of renal epithelial cells in vitro .
Authors
- Peter C. Harris (ORCID: https://orcid.org/0000-0002-5304-6593)
- Courtney J. Haycraft
- Cynthia J. Sieben (ORCID: https://orcid.org/0000-0002-6733-7711)
- Bradley K. Yoder (ORCID: https://orcid.org/0000-0002-0247-1944)
- Mandy J. Croyle (ORCID: https://orcid.org/0000-0001-5208-0530)
- Jinghua Hu (ORCID: https://orcid.org/0000-0001-9635-9779)
- Kun Ling (ORCID: https://orcid.org/0000-0002-2388-5492)
- Kai He (ORCID: https://orcid.org/0000-0001-6405-8330)
- Madilyn R. Ellis (ORCID: https://orcid.org/0009-0009-7152-6556)
- Jielu Hao Robichaud
- Chuan Chen (ORCID: https://orcid.org/0000-0002-0694-0867)
- Chunhua Chen (ORCID: https://orcid.org/0000-0001-7248-5041)
- Zhifei Wang (ORCID: https://orcid.org/0000-0002-5494-6745)
- Yue Gao (ORCID: https://orcid.org/0009-0006-9470-6443)
- Yong Yu (ORCID: https://orcid.org/0000-0002-1849-0779)
- Qingwen Xu (ORCID: https://orcid.org/0000-0002-4796-3141)
- Yan Huang (ORCID: https://orcid.org/0009-0001-3884-2559)
- Biyun Ji (ORCID: https://orcid.org/0009-0000-9027-8150)
- Ariana Aghevli
Institutions
- Mayo Clinic (US)
- St. John's University (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1681/asn.0000000942
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00