Bridging Radiology and Pathology: ATRX Loss and T2-FLAIR Mismatch as Early Diagnostic and Prognostic Markers in Diffuse Gliomas
ATRX mutation and the T2-FLAIR mismatch sign have emerged as complementary molecular and imaging markers in diffuse gliomas. ATRX loss defines IDH-mutant astrocytoma at the molecular level, while the mismatch sign provides a non-invasive radiological clue with high specificity but limited sensitivity. Used together, they improve diagnostic precision, refine prognostic assessment, and guide individualized treatment planning.
Authors
- Muhammad Shahzad Shamim (ORCID: https://orcid.org/0000-0001-6081-9454)
- Irfan Yousaf (ORCID: https://orcid.org/0000-0003-4992-5154)
- Aaqib Sohail (ORCID: https://orcid.org/0000-0002-5917-7316)
- Quratulain Tariq
- Endris Mohammed Ali (ORCID: https://orcid.org/0009-0003-3350-1936)
- Rahamah Arshad
Institutions
- CMH Lahore Medical College and Institute of Dentistry (PK)
- Aga Khan University Hospital (PK)
- Shaukat Khanum Memorial Cancer Hospital and Research Center (PK)
Publication Details
- Journal
- Journal of the Pakistan Medical Association
- Published
- 2025-11-22
- DOI
- https://doi.org/10.47391/jpma.25-106
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00