Association between lid margin collarettes and dry eye disease severity in the Dry Eye Assessment and Management (DREAM) study
Collarettes were common in patients with moderate-to-severe DED, and most do not progress over time. Although they were associated with worse ocular surface signs, notably eyelid erythema, no association was found with dry eye symptoms. Our results will help physicians counsel and guide the approach to treating dry eye patients with collarettes, and generate pilot data for tear film biomarker identification.
Authors
- Meng C. Lin (ORCID: https://orcid.org/0000-0003-4301-0279)
- Rony R. Sayegh (ORCID: https://orcid.org/0000-0002-0119-4201)
- Penny A. Asbell (ORCID: https://orcid.org/0000-0001-9124-0904)
- Eliot N. Haddad (ORCID: https://orcid.org/0000-0002-9207-7325)
- Gui‐Shuang Ying (ORCID: https://orcid.org/0000-0002-5752-1355)
- Patrick Augello (ORCID: https://orcid.org/0009-0003-5897-3497)
- Alexander E. Azar (ORCID: https://orcid.org/0009-0000-8037-6953)
Institutions
- Cleveland Clinic (US)
- Cleveland Clinic Lerner College of Medicine (US)
- University School (US)
- Cleveland Eye Clinic (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
- Temple University (US)
- University of Memphis (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Eye
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1038/s41433-025-04105-5
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health