Signature ECG part 5: Exercise induced syncope

14-year-old boy presented with aborted sudden cardiac arrest during exertion. His brother died suddenly at 16 years of age during an emotional situation. On stress testing, patient developed classical bidirectional PVCs typical of CPVT (Catecholaminergic polymorphic ventricular tachycardia). The genetic testing showed pathogenic heterozygous variant in CASQ<sub>2</sub> gene. Patient was started on propranolol and flecainide and advised to avoid strenuous physical activity.

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Publication Details

Journal
Indian Pacing and Electrophysiology Journal
Published
2025-11-25
DOI
https://doi.org/10.1016/j.ipej.2025.11.010
Citations
1
Primary Topic
Cardiac electrophysiology and arrhythmias
Type
article
Field-Weighted Citation Impact
1.39
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article

Signature ECG part 5: Exercise induced syncope

Anand Manickavasagam, Arthur A M Wilde
1 citations
Indian Pacing and Electrophysiology Journal
Cardiac electrophysiology and arrhythmias
1.39
article

Signature ECG part 5: Exercise induced syncope

Anand Manickavasagam, Arthur A M Wilde
article en
1 citations

Abstract

14-year-old boy presented with aborted sudden cardiac arrest during exertion. His brother died suddenly at 16 years of age during an emotional situation. On stress testing, patient developed classical bidirectional PVCs typical of CPVT (Catecholaminergic polymorphic ventricular tachycardia). The genetic testing showed pathogenic heterozygous variant in CASQ<sub>2</sub> gene. Patient was started on propranolol and flecainide and advised to avoid strenuous physical activity.

Indian Pacing and Electrophysiology JournalVol. 26(1)
Christian Medical College, Vellore (IN), Christian Medical College (IN), Amsterdam University Medical Centers (NL), University of Amsterdam (NL)
Openalex Percentile: Top 13%
Cardiac electrophysiology and arrhythmias
1.39
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