Association of donor and recipient single-nucleotide polymorphisms of interleukin-1 gene with outcomes after allogeneic hematopoietic stem cell transplantation in childhood
Our study identified the donor IL-1α rs1800587 CC/CT genotype as a possible genetic risk factor for developing moderate to severe acute GVHD (grade II - IV) in pediatric patients who underwent allogeneic HSCT. Once confirmed in further studies, these results may influence the donor selection and prophylaxis to decrease the risk of acute GVHD in children.
Authors
- Bernd Gruhn (ORCID: https://orcid.org/0000-0003-1862-0075)
- Susan Wittig
- Katharina Kämpfner
Institutions
- Jena University Hospital (DE)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1007/s00432-025-06380-x
- Citations
- 1
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.80