Lactose breath test in adults: Are symptoms predictive of lactose malabsorption?

In adults with unexplained functional gastrointestinal symptoms, standardized symptom recording during lactose breath testing provides clinically useful context, with flatulence emerging as the most informative symptom for LM. Grading intolerance according to symptom severity effectively helps to identify lactose malabsorbers. Adding methane measurements may further improve diagnostic accuracy. Overall, these findings support an individualized diagnostic pathway that blends gas profiling with standardized symptom scoring-guiding targeted management while limiting unnecessarily restrictive diets.

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Publication Details

Journal
Clinical Nutrition ESPEN
Published
2025-11-25
DOI
https://doi.org/10.1016/j.clnesp.2025.11.151
Primary Topic
Digestive system and related health
Type
article
Field-Weighted Citation Impact
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article

Lactose breath test in adults: Are symptoms predictive of lactose malabsorption?

D. Cassella, Carolina Cavazzuti, Giovanni Maconi, Bárbara Rossi et al.
Clinical Nutrition ESPEN
Digestive system and related health
article

Lactose breath test in adults: Are symptoms predictive of lactose malabsorption?

D. Cassella, Carolina Cavazzuti, Giovanni Maconi, Bárbara Rossi, Alessandra Dell’Era, Nunzio Zignani
article en

Abstract

In adults with unexplained functional gastrointestinal symptoms, standardized symptom recording during lactose breath testing provides clinically useful context, with flatulence emerging as the most informative symptom for LM. Grading intolerance according to symptom severity effectively helps to identify lactose malabsorbers. Adding methane measurements may further improve diagnostic accuracy. Overall, these findings support an individualized diagnostic pathway that blends gas profiling with standardized symptom scoring-guiding targeted management while limiting unnecessarily restrictive diets.

Clinical Nutrition ESPENVol. 72
Luigi Sacco Hospital (IT), ASST Fatebenefratelli Sacco (IT)
Openalex Percentile: Top 62%
Digestive system and related health
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