Current advances in platelet-rich plasma therapy for erectile dysfunction: a meta-analysis of randomized controlled trials
Current evidence does not support a consistent, clinically meaningful improvement in erectile function with PRP monotherapy compared with placebo. Despite an encouraging mechanistic rationale and safety profile, the high heterogeneity, small sample sizes, and methodological limitations of existing RCTs limit confidence in efficacy. Larger, standardized, double-blind trials with rigorous protocols are needed to clarify the role of PRP in ED management.
Authors
- D. Jacob (ORCID: https://orcid.org/0009-0003-8953-6492)
- Ian Pearce (ORCID: https://orcid.org/0000-0002-7710-0531)
- Elia Abou Chawareb (ORCID: https://orcid.org/0000-0002-0757-896X)
- Mohamed Mubarak (ORCID: https://orcid.org/0000-0003-1611-999X)
- Vaibhav Modgil (ORCID: https://orcid.org/0009-0009-1517-6184)
- Muhammad Shariq Rahemtoola (ORCID: https://orcid.org/0000-0002-7185-069X)
- Faysal A. Yafi (ORCID: https://orcid.org/0000-0001-7847-0246)
- Muhammed Hammad (ORCID: https://orcid.org/0000-0001-5396-1364)
- J. Hay
- Simone Sim
- Lois Libretto
Institutions
- University of California, Irvine (US)
- St Mary's Hospital (GB)
Publication Details
- Journal
- The Journal of Sexual Medicine
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1093/jsxmed/qdaf325
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00