High-efficiency generation of blastoids with gastrulation potential through Gata4-induced PrE specification in mESCs

Authors

Leqian Yu (ORCID: https://orcid.org/0000-0003-2060-463X)
Peng Du (ORCID: https://orcid.org/0009-0008-3768-1758)
Guihai Feng (ORCID: https://orcid.org/0000-0002-8726-1734)
Qi Gu (ORCID: https://orcid.org/0000-0001-9387-9525)
Wei Li (ORCID: https://orcid.org/0000-0001-7864-404X)
Hongmei Wang (ORCID: https://orcid.org/0000-0003-1603-4785)
Dong Li (ORCID: https://orcid.org/0000-0003-1630-1214)
Yanhong Xu
Xin Li (ORCID: https://orcid.org/0000-0002-9064-5114)
Shuyang Jiang
Huanhuan Wu (ORCID: https://orcid.org/0000-0002-0104-9346)
Xiaohang Ma
Cheng Huang (ORCID: https://orcid.org/0000-0002-7149-9879)
Chaofan He
Fu Guo

Institutions

Chinese Academy of Sciences (CN)
Peking University (CN)
Institute for Stem Cell Biology and Regenerative Medicine (IN)
Center for Life Sciences (CN)
University of Chinese Academy of Sciences (CN)
Institute of Zoology (CN)

Publication Details

Journal: Cell Discovery
Published: 2025-11-25
DOI: https://doi.org/10.1038/s41421-025-00849-2
Primary Topic: Congenital heart defects research
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Chinese Academy of Sciences
Institute of Zoology, Chinese Academy of Sciences
Beijing Obstetrics and Gynecology Hospital, Capital Medical University

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article

High-efficiency generation of blastoids with gastrulation potential through Gata4-induced PrE specification in mESCs

Leqian Yu, Peng Du, Guihai Feng, Qi Gu et al.

Nov 25, 2025

Cell Discovery

Congenital heart defects research

article

High-efficiency generation of blastoids with gastrulation potential through Gata4-induced PrE specification in mESCs

Leqian Yu, Peng Du, Guihai Feng, Qi Gu, Wei Li, Hongmei Wang, Dong Li, Yanhong Xu, Xin Li, Shuyang Jiang, Huanhuan Wu, Xiaohang Ma, Cheng Huang, Chaofan He, Fu Guo

November 25, 2025article en

Abstract

No abstract available for this paper.

Cell DiscoveryVol. 11(1)

Chinese Academy of Sciences (CN), Peking University (CN), Institute for Stem Cell Biology and Regenerative Medicine (IN), Center for Life Sciences (CN), University of Chinese Academy of Sciences (CN), Institute of Zoology (CN)

Chinese Academy of Sciences, Institute of Zoology, Chinese Academy of Sciences, Beijing Obstetrics and Gynecology Hospital, Capital Medical University

Openalex Percentile: Top 67%

Congenital heart defects research

DOI Open Access PDF OpenAlex

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High-efficiency generation of blastoids with gastrulation potential through Gata4-induced PrE specification in mESCs — Leqian Yu, Peng Du, et al. · Cell Discovery (2025) | TGRS Research Map | TGRS