Mapping the Severe Asthma Questionnaire to EQ-5D-5L health utility scores in the SHARP CRC registry

<bold>Rationale</bold> The Severe Asthma Questionnaire (SAQ) provides insight into patients' perceptions of severe asthma. However, policy makers often prefer preference-based measures (PBMs) as the EuroQol-5D-5L (EQ5D5L) to estimate health-related quality of life for use in health-economic evaluations. <bold>Aim</bold> To develop mapping algorithms based on the SAQ score and SAQ domains for the EQ5D5L health utility scores. <bold>Methods</bold> We included all 316 patients with EQ5D5L data (7 countries, 55% female, mean age 54 (SD 13)) years, 77% on biologics, mean ACQ6 score 1.7 (SD 1.3), mean SAQ score 5.1 (SD 1.6) from the Severe Heterogeneous Asthma Research collaboration Patient-centred (SHARP) registry. Direct mapping of the EQ5D5L index (OLS, betamix regression) or indirect mapping (oprobit) of the 5 dimensions: mobility; self-care; usual activities; pain/discomfort; anxiety/depression) was based on the SAQ score and SAQ domains (my life: impact on life activities; my mind: emotional impact; my body: impact on extra-pulmonary symptoms and side effects). Model performance was based on the mean (SD), (lowest) root mean square error (RMSE) and the explained variance (R2). <bold>Results</bold> <fig><object-id>erj;66/suppl_69/PA3643/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig> <bold>CONCLUSION</bold> In the absence of the preference-based EQ5D5L, the indirect mapping of SAQ domains-based algorithm provides a good alternative for predicting the health utility in patients with severe asthma for use in health-economic evaluations. <bold>Funding:</bold> SHARP CRC, RAPSODI

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Published
2025-09-27
DOI
https://doi.org/10.1183/13993003.congress-2025.pa3643
Primary Topic
Health Systems, Economic Evaluations, Quality of Life
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article
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article

Mapping the Severe Asthma Questionnaire to EQ-5D-5L health utility scores in the SHARP CRC registry

Anneke Ten Brinke, Dawn Redwood, J. Tilley, Sabina Škrgat et al.
Health Systems, Economic Evaluations, Quality of Life
article

Mapping the Severe Asthma Questionnaire to EQ-5D-5L health utility scores in the SHARP CRC registry

Anneke Ten Brinke, Dawn Redwood, J. Tilley, Sabina Škrgat, Jacob K. Sont, Matthew Masoli, Marina Isabel Vieira Antunes Cunha, Simon Doe, M. Elske van den Akker‐van Marle, Inês Farinha, Fleur L. Meulmeester, Kristina Biekšienė, Barbro Dahlén, Pedro Nogueira Costa, L. Havé, Valentyna Yasinska, Thomas W. Wainwright, Joseph Lanario, Sanja Hromiš, Peter Kopač, Cláudia Chaves Loureiro, Mariana Paula-Rezelj, Ana Žaže Bertoncel, Oksana Tenzelius, Kathleen Bayani, Dominique Hamerlynck
article en

Abstract

<bold>Rationale</bold> The Severe Asthma Questionnaire (SAQ) provides insight into patients' perceptions of severe asthma. However, policy makers often prefer preference-based measures (PBMs) as the EuroQol-5D-5L (EQ5D5L) to estimate health-related quality of life for use in health-economic evaluations. <bold>Aim</bold> To develop mapping algorithms based on the SAQ score and SAQ domains for the EQ5D5L health utility scores. <bold>Methods</bold> We included all 316 patients with EQ5D5L data (7 countries, 55% female, mean age 54 (SD 13)) years, 77% on biologics, mean ACQ6 score 1.7 (SD 1.3), mean SAQ score 5.1 (SD 1.6) from the Severe Heterogeneous Asthma Research collaboration Patient-centred (SHARP) registry. Direct mapping of the EQ5D5L index (OLS, betamix regression) or indirect mapping (oprobit) of the 5 dimensions: mobility; self-care; usual activities; pain/discomfort; anxiety/depression) was based on the SAQ score and SAQ domains (my life: impact on life activities; my mind: emotional impact; my body: impact on extra-pulmonary symptoms and side effects). Model performance was based on the mean (SD), (lowest) root mean square error (RMSE) and the explained variance (R2). <bold>Results</bold> <fig><object-id>erj;66/suppl_69/PA3643/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig> <bold>CONCLUSION</bold> In the absence of the preference-based EQ5D5L, the indirect mapping of SAQ domains-based algorithm provides a good alternative for predicting the health utility in patients with severe asthma for use in health-economic evaluations. <bold>Funding:</bold> SHARP CRC, RAPSODI

Lithuanian University of Health Sciences (LT), University of Novi Sad (RS), University of Exeter (GB), Leiden University Medical Center (NL), Musgrove Park Hospital (GB), Ljubljana University Medical Centre (SI), British Lung Foundation (GB), Hospitais da Universidade de Coimbra (PT), Medisch Centrum Leeuwarden (NL), Karolinska Institutet (SE), Svenska Örtmedicinska Institute (SE), University Clinic of Pulmonary and Allergic Diseases Golnik (SI), Newcastle upon Tyne Hospital (GB), Swedish Asthma and Allergy Association (SE), Newcastle University (GB), University of Plymouth (GB)
Openalex Percentile: Top 56%
Health Systems, Economic Evaluations, Quality of Life
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