Unlocking Asthma Remission: Key Insights from an Expert Roundtable Discussion
<bold>Background:</bold> Treatment targets in severe asthma have evolved towards a remission-focused paradigm guided by precision medicine. However, the concept is still emerging. <bold>Objective:</bold> To understand the strengths, weaknesses, confounders, application and future of the current construct of asthma remission. <bold>Methods:</bold> A hybrid face-to-face and virtual roundtable discussion was held on the 30th of April 2024. The summary of discussions is narratively synthesised. <bold>Results:</bold> The participants (n=27 international asthma experts) observed that between one in three to one in five people treated with biologics/macrolides experience low disease activity over a sustained period. Labelling the attained clinical state as clinical remission is useful as a clinical, policy and scientific tool. Current remission rates vary significantly due to definition variability. The minimum requirements of asthma remission have been proposed. When assessing remission, it is essential to consider confounding factors. More research is required to reach an acceptable definition, and including the patient's voice in such research is essential. The themes discussed and the suggestions are summarised in Figure 1. <bold>Conclusion:</bold> The concept of treatment-induced clinical remission is possible and valuable in asthma. However, further refinement of the definition is required. <fig><object-id>erj;66/suppl_69/PA3651/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>
Authors
- Kirsty Murray
- Eleanor Majellano (ORCID: https://orcid.org/0000-0002-9566-5181)
- Matthew Peters (ORCID: https://orcid.org/0000-0002-1938-2518)
- Gary P. Anderson (ORCID: https://orcid.org/0000-0001-6580-3398)
- Constance H. Katelaris (ORCID: https://orcid.org/0000-0002-4412-1336)
- John Harrington (ORCID: https://orcid.org/0000-0003-1542-6250)
- Vanessa Clark (ORCID: https://orcid.org/0000-0003-3450-5843)
- Anne E. Holland (ORCID: https://orcid.org/0000-0003-2061-845X)
- Peter A. B. Wark (ORCID: https://orcid.org/0000-0001-5676-6126)
- Philip G. Bardin (ORCID: https://orcid.org/0000-0002-9596-574X)
- John W. Upham (ORCID: https://orcid.org/0000-0002-0017-3433)
- Claude S. Farah (ORCID: https://orcid.org/0000-0003-2489-227X)
- Peter G. Gibson (ORCID: https://orcid.org/0000-0001-5865-489X)
- Katrina O. Tonga (ORCID: https://orcid.org/0000-0002-8594-366X)
- Jimmy Chien (ORCID: https://orcid.org/0000-0001-5303-5395)
- Christine Jenkins (ORCID: https://orcid.org/0000-0003-2717-5647)
- Dennis Thomas (ORCID: https://orcid.org/0000-0003-4182-6821)
- Gregory Katsoulotos
- Hayley Lewthwaite (ORCID: https://orcid.org/0000-0002-5212-2937)
- Richard Beasley (ORCID: https://orcid.org/0000-0003-0337-406X)
- Vanessa M. McDonald (ORCID: https://orcid.org/0000-0001-9890-3408)
- Michael Fricker (ORCID: https://orcid.org/0000-0002-8587-1774)
- Erin S. Harvey (ORCID: https://orcid.org/0000-0002-7647-8858)
- Mark Hew (ORCID: https://orcid.org/0000-0002-7498-0000)
- Vibeke Backer (ORCID: https://orcid.org/0000-0002-7806-7219)
- Yuto Hamada (ORCID: https://orcid.org/0000-0002-3234-652X)
- R. L. Thomas
Institutions
- Camden and Campbelltown Hospitals (AU)
- Concord Hospital (US)
- The University of Melbourne (AU)
- Concord Repatriation General Hospital (AU)
- John Hunter Hospital (AU)
- Princess Alexandra Hospital (AU)
- The Alfred Hospital (AU)
- Copenhagen University Hospital (DK)
- Hudson Institute of Medical Research (AU)
- Rigshospitalet (DK)
- Westmead Hospital (AU)
- Hunter Medical Research Institute (AU)
- National Sagamihara Hospital (JP)
- Monash Health (AU)
- St Vincent's Clinic (AU)
- Medical Research Institute of New Zealand (NZ)
- Melbourne Health (AU)
- Alfred Health (AU)
- Monash University (AU)
- The University of Notre Dame Australia (AU)
- Macquarie University (AU)
Publication Details
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1183/13993003.congress-2025.pa3651
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00