Acute Fever Early Post Renal Transplantation—A Call From the Tropics
Infection with Dengue virus (DENV)is a growing concern in solid organ transplant (SOT) recipients in endemic regions. We report a 15-year-old kidney transplant recipient who developed fever and thrombocytopenia on post-transplant day five; DENV NS1 antigen confirmed acute infection. He recovered with supportive care, and no donor-derived transmission was identified. A review of 327 cases shows early post-transplant dengue carries higher risks of cytopenias, capillary leak, graft dysfunction, and mortality (6.1%) versus the general population. Improved diagnostics, outbreak-responsive donor screening, and pre-transplant vaccination in immunocompetent candidates may help mitigate dengue burden in SOT recipients.
Authors
- Sadid F Khan (ORCID: https://orcid.org/0000-0002-1882-7423)
- Wanessa Trindade Clemente (ORCID: https://orcid.org/0000-0003-0848-3740)
- Siriorn P. Watcharananan (ORCID: https://orcid.org/0000-0002-8464-9709)
- Ban Hock Tan (ORCID: https://orcid.org/0000-0002-1458-9456)
- Rahana Abd Rahman (ORCID: https://orcid.org/0000-0003-4161-6461)
- Daniel Wagner de Castro Lima Santos (ORCID: https://orcid.org/0000-0003-4946-911X)
Institutions
- Universidade Federal de Minas Gerais (BR)
- ASTER (CA)
- Singapore General Hospital (SG)
- D’Or Institute for Research and Education (BR)
- Hospital Universitário da Universidade Federal do Maranhão (BR)
- Hospital das Clínicas da Universidade Federal de Minas Gerais (BR)
- Ramathibodi Hospital (TH)
- Alfred Health (AU)
- Universidade Federal do Maranhão (BR)
- Monash University (AU)
Publication Details
- Journal
- Transplant Infectious Disease
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1111/tid.70141
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00