MODY Is Prevalent in Later-Onset Diabetes and Has Potential for Targeted Therapy but Is Challenging to Identify
Maturity-onset diabetes of the young (MODY) can present later in life, and diagnosis can enable precision treatment. However, individuals with later-onset diabetes are rarely tested. How common is MODY in people diagnosed with diabetes after age 40 years? Can they be identified clinically? MODY affects 1 in 191-633 individuals with diabetes onset after 40 years, but clinical features alone cannot reliably identify them. MODY is relatively common in later-onset diabetes but difficult to detect clinically, limiting routine genetic testing in this group.
Authors
- Kevin Colclough (ORCID: https://orcid.org/0000-0003-0566-4853)
- Stuart J Cannon (ORCID: https://orcid.org/0000-0002-5108-7615)
- Uyenlinh L. Mirshahi (ORCID: https://orcid.org/0000-0003-4972-5451)
- Luke N Sharp (ORCID: https://orcid.org/0009-0001-3657-5493)
- Thomas W. Laver (ORCID: https://orcid.org/0000-0001-6399-0089)
- Jeremy S. Haley (ORCID: https://orcid.org/0000-0002-3279-7873)
- Andrew Tym Hattersley (ORCID: https://orcid.org/0000-0001-5620-473X)
- David J. Carey (ORCID: https://orcid.org/0000-0001-6404-1950)
- Kashyap Patel (ORCID: https://orcid.org/0000-0002-9240-8104)
- Michael N. Weedon (ORCID: https://orcid.org/0000-0002-6174-6135)
- Timothy S. Hall
Institutions
- University of Exeter (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- NIHR Exeter Clinical Research Facility (GB)
- Geisinger Health System (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-11-25
- DOI
- https://doi.org/10.2337/db25-0545
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00