PBX1 promotes osteoporosis by upregulating HMGB1 to suppress osteogenic differentiation of bone marrow mesenchymal stem cells
PBX1 acts as an upstream transcriptional regulator that suppresses osteogenic differentiation in part by activating HMGB1, and pharmacological inhibition of PBX1 restores osteogenic potential.
Authors
- Zhong Liu (ORCID: https://orcid.org/0000-0003-3067-1967)
- Yang Yang (ORCID: https://orcid.org/0000-0002-8190-1825)
Institutions
- Changsha Medical University (CN)
- Xiangyang Central Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s13287-025-04832-2
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00