Histone lactylation drives METTL3 upregulation-mediated RNA m6A modification of CCT2 to hinder CD8+ T cell survival in gastric cancer
Histone lactylation drives upregulation of METTL3 and mediates m6A modification and overexpression of CCT2. CCT2 dampens the activity of CD8<sup>+</sup>T cells by repressing Ca<sup>2+</sup>influx, thereby mediating the malignant progression of GC.
Authors
- Fang Wu (ORCID: https://orcid.org/0000-0002-6627-3437)
- Jason Jisheng Wu (ORCID: https://orcid.org/0009-0004-1583-4240)
- Zai‐yuan Ye (ORCID: https://orcid.org/0009-0001-9233-9663)
- Xufan Cai
- Zhenyuan Qian
Institutions
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1007/s00018-025-05955-8
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00