Selaginella extracts extend lifespan and mitigate oxidative stress in Caenorhabditis elegans
Our findings demonstrate that <i>Selaginella</i> extract and its key component, amentoflavone, delay aging primarily by activating the DAF-16/FOXO transcription factor and bolstering the antioxidant defense system. This study not only highlights amentoflavone as a major contributor to the lifespan-extending effects of Selaginella but also underscores the potential of these natural compounds as promising agents for healthy aging.
Authors
- Zhaohua Shi
- Wu-Yong Quan
- Bixin Yan (ORCID: https://orcid.org/0009-0005-8017-6691)
- Junbo Gou (ORCID: https://orcid.org/0000-0002-6687-729X)
- Yuan Wang (ORCID: https://orcid.org/0000-0003-3112-3831)
- Yu Liu (ORCID: https://orcid.org/0000-0003-2444-3079)
- Jin Wang (ORCID: https://orcid.org/0000-0003-4957-5553)
- Yifei Liu (ORCID: https://orcid.org/0000-0002-4234-3365)
- Pan Li
- Songlin Liu (ORCID: https://orcid.org/0000-0002-2985-0266)
- Qi Zhou (ORCID: https://orcid.org/0000-0002-0441-584X)
- Yang Shao (ORCID: https://orcid.org/0000-0001-8808-7144)
- Yihong Huang (ORCID: https://orcid.org/0000-0002-9962-3632)
- Xueqing Chen
- Peng Shu (ORCID: https://orcid.org/0000-0002-5970-9992)
- Yingmei Wu (ORCID: https://orcid.org/0000-0003-4802-7897)
Institutions
- South China Agricultural University (CN)
- Hubei University of Chinese Medicine (CN)
- h2med (United States) (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fphar.2025.1658991
- Primary Topic
- Biological Activity of Diterpenoids and Biflavonoids
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Huazhong Agricultural University
- Hubei University