Mutational landscape of gastrointestinal stromal tumors using next-generation sequencing of a 73-gene panel
Using a 73-gene panel, we characterized the molecular characteristics of GISTs and revealed a correlation with their clinical features. Moreover, KIT/PDGFRA-dependent and KIT/PDGFRA-independent mechanisms underlying resistance to imatinib were explored. Overall, our 73-gene panel is sufficient for clinical application in cases of GISTs.
Authors
- Zhidong Gao (ORCID: https://orcid.org/0000-0002-8415-7587)
- Yingjiang Ye (ORCID: https://orcid.org/0000-0002-7904-3163)
- Huan Yin (ORCID: https://orcid.org/0009-0001-0800-8651)
- Chang Wang (ORCID: https://orcid.org/0000-0002-9410-1878)
- Wei Wang (ORCID: https://orcid.org/0009-0003-7539-9394)
- Chao Wang (ORCID: https://orcid.org/0000-0002-0812-904X)
- Rongrong Chen (ORCID: https://orcid.org/0000-0002-5362-2116)
- Yuqing Wu (ORCID: https://orcid.org/0000-0002-7376-4971)
- Baosen Cheng (ORCID: https://orcid.org/0009-0001-2146-1020)
- Yuanyuan Xiong
- Shuya Yang
Institutions
- King University (US)
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Peking University People's Hospital (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12957-025-04085-6
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00