Metabolomic and microbiome integration of Han-Tibetan and plain-plateau populations
This study identified significant associations between metabolic, lipid, and microbial differences and altitude-induced physiological variation, illustrating population adaptations to extreme environments. Our systematic comparative analysis improves our understanding of high-altitude adaptability, underlining the importance of integrating metabolic and microbiological analyses and facilitating future research on associated disorders.
Authors
- Kaikai Guo (ORCID: https://orcid.org/0000-0002-4219-5171)
- Xiaojing Zhao (ORCID: https://orcid.org/0000-0002-4937-9088)
- Kunlun He (ORCID: https://orcid.org/0000-0002-3335-5700)
- Shihui Fu (ORCID: https://orcid.org/0000-0001-6707-9049)
- Lindsey Han (ORCID: https://orcid.org/0000-0002-7357-3067)
- Aijing Geng
- Li‐Lin Du (ORCID: https://orcid.org/0000-0002-1028-7397)
- Chong Yin (ORCID: https://orcid.org/0000-0002-8113-8911)
- Jinlong Shi (ORCID: https://orcid.org/0009-0002-9538-9508)
- Pei Li (ORCID: https://orcid.org/0000-0002-2681-8842)
- Zhihan Wang (ORCID: https://orcid.org/0000-0002-3617-477X)
- Jinxiu Sun (ORCID: https://orcid.org/0000-0001-9749-0779)
Institutions
- Chengdu Medical College (CN)
- Chinese PLA General Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Hainan 301 Hospital (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12915-025-02430-5
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- General Hospital of People’s Liberation Army