A new strategy for the diagnosis of tuberculosis based on secreted antigens: evaluation of the efficacy of alveolar lavage ESAT-6 and CFP-10 tests
(1) ESAT-6 and CFP-10 detection in BALF significantly improves PTB diagnostic sensitivity, unaffected by bacterial load, particularly benefiting the diagnosis of bacteriologically negative PTB. (2) Combined antigen testing strategies (parallel/tandem) optimally balance sensitivity and specificity, meeting clinical requirements for ruling out or confirming PTB diagnosis.
Authors
- Jie‐Gen Jiang
- Jie Sun (ORCID: https://orcid.org/0000-0002-5642-0560)
- Feng Liu (ORCID: https://orcid.org/0000-0002-0316-4938)
- Shiyu Fang (ORCID: https://orcid.org/0009-0008-1848-3481)
Institutions
- North Sichuan Medical University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s40001-025-03449-8
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00