A novel BMSC-derived Exosomal circrna promotes angiogenesis by targeting miR-34a-5p to regulate Piezo1
This study provides the first reported circRNA profile of BMSC-derived exosomes in SONFH, identifying novel_circ_0001686 as a key regulator of angiogenesis. By acting through the novel_circ_0001686/miR-34a-5p/Piezo1 axis, it enhances endothelial function and vascular remodeling. These findings imply that novel_circ_0001686 is a promising therapeutic target, underscoring the potential of exosome-based strategies for restoring vascularization and bone homeostasis in SONFH.
Authors
- Weipeng Shi (ORCID: https://orcid.org/0000-0002-1471-2784)
- Sijia Guo
- Tao Li (ORCID: https://orcid.org/0000-0002-0034-6939)
- Yingzhen Wang (ORCID: https://orcid.org/0009-0002-8157-8594)
- Zehua Zhou (ORCID: https://orcid.org/0000-0002-8409-6307)
- Yaping Jiang (ORCID: https://orcid.org/0009-0001-8894-7607)
- Xiaoxia Li (ORCID: https://orcid.org/0000-0002-4872-9525)
- Tingyu Wu (ORCID: https://orcid.org/0000-0003-1610-6136)
- Yinxue Zhou
Institutions
- Qingdao University (CN)
- Tongji University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s13287-025-04769-6
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China