Neuron-derived extracellular vesicles reflect adaptive neuronal responses to cortical spreading depolarization: a biomarker study for migraine
Our results highlight the potential of nEVs as dynamic reporters of cortical neuronal activity in a migraine model. Significant changes in nEV proteome suggest that the neuronal response to CSD extends beyond inflammatory signaling and encompasses adaptive mechanisms aimed at maintaining cellular homeostasis and synaptic integrity. Given their accessibility through peripheral fluids and potential capacity to reflect dynamic changes in neurons, nEVs emerge as promising candidates for investigating pathophysiology and biomarker identification in migraine.
Authors
- Canan Cakir-Aktas (ORCID: https://orcid.org/0000-0002-3401-3892)
- Turgay Dalkara (ORCID: https://orcid.org/0000-0003-3943-7819)
- Şefik Evren Erdener (ORCID: https://orcid.org/0000-0002-5141-7899)
- Melike Sever (ORCID: https://orcid.org/0000-0002-0592-9666)
- Nevin Belder (ORCID: https://orcid.org/0000-0001-9353-9387)
- Bengisu Solgun (ORCID: https://orcid.org/0000-0003-4453-1287)
- Ülkü Güler (ORCID: https://orcid.org/0000-0001-6914-9362)
- Bekir Salih (ORCID: https://orcid.org/0000-0002-8542-6531)
- Buket Onat (ORCID: https://orcid.org/0000-0001-6349-5854)
- Mehtap Şahin (ORCID: https://orcid.org/0000-0003-4518-6489)
Institutions
- Ankara University (TR)
- Bilkent University (TR)
- Hacettepe University (TR)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s10194-025-02213-x
- Citations
- 2
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Türkiye Bilimler Akademisi
- Hacettepe Üniversitesi
- Bilkent Üniversitesi