Development of a standardized ovine aortic stenosis model: a pathomimetic platform for TAVI evaluation and durability testing
The surgically induced ovine AS model effectively replicates clinically relevant hemodynamic perturbations while maintaining excellent procedural feasibility. TAVI in this model achieves complete hemodynamic normalization without accelerating bioprosthetic valve degeneration or calcification. This standardized preclinical platform enables rigorous evaluation of TAVI device performance and durability, providing robust scientific validation for translational applications.
Authors
- X Q Tong
- Xin Lin
- Yan Zhu (ORCID: https://orcid.org/0000-0002-3672-7127)
- Jie Hou (ORCID: https://orcid.org/0000-0003-2349-9230)
- Mengsi Hu
- B Li (ORCID: https://orcid.org/0009-0006-4486-6115)
- Zhuo Chen (ORCID: https://orcid.org/0000-0001-6555-0319)
- Xin Jiang (ORCID: https://orcid.org/0000-0003-1794-5986)
- Xufeng Wei (ORCID: https://orcid.org/0000-0002-0321-806X)
- Fangxu Liu (ORCID: https://orcid.org/0009-0000-2074-4304)
- Dejian Li (ORCID: https://orcid.org/0000-0003-3566-3464)
- Nana Qin (ORCID: https://orcid.org/0009-0009-4437-2678)
Institutions
- Shandong University (CN)
- Hisense (China) (CN)
- Shandong Provincial Hospital (CN)
- General Hospital of Shenyang Military Region (CN)
- Hongzhiwei Technology (China) (CN)
- Wuxi Taihu Hospital (CN)
- Wuxi People's Hospital (CN)
- Shandong First Medical University (CN)
- Shanxi Cardiovascular Hospital (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fcvm.2025.1663130
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province