Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression
Our study confirms that pharmacological blockade of ACC1 significantly inhibits de novo lipogenesis and CCA tumorigenesis, suggesting that WA may serve as a potential small-molecule inhibitor targeting lipid metabolism for CCA treatment.
Authors
- Hong‐Wen Liu (ORCID: https://orcid.org/0000-0001-8757-1620)
- Dongyin Chen (ORCID: https://orcid.org/0000-0002-7978-7429)
- Yani Pan (ORCID: https://orcid.org/0000-0002-4755-9878)
- Zhangding Wang (ORCID: https://orcid.org/0000-0002-3959-4542)
- Lei Wang (ORCID: https://orcid.org/0000-0001-8172-5334)
- Lei Xu (ORCID: https://orcid.org/0000-0002-9241-7019)
- Xinyu Wang (ORCID: https://orcid.org/0000-0003-0806-4335)
- Qiang Wang (ORCID: https://orcid.org/0000-0003-0000-9139)
- Yue Zhou (ORCID: https://orcid.org/0009-0006-5132-3741)
- Yuxiang Ma (ORCID: https://orcid.org/0000-0003-1173-8441)
- Yun Zhu
- Xin Fu (ORCID: https://orcid.org/0000-0001-9726-9388)
- Qi Chen
- Nannan Zhang
Institutions
- Anhui Medical University (CN)
- Nanjing Drum Tower Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- YangPu Geriatric Hospital (CN)
- Yangpu Hospital of Tongji University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s13046-025-03564-8
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00