The LIFE-MET trial: effect of insulin sensitization on pubertal progression following lifestyle intervention and/or treatment with metformin in girls with early puberty and overweight: study protocol for a randomized, placebo-controlled trial

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Journal
Trials
Published
2025-11-25
DOI
https://doi.org/10.1186/s13063-025-09229-3
Primary Topic
Hypothalamic control of reproductive hormones
Type
article
Field-Weighted Citation Impact
0.00

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article

The LIFE-MET trial: effect of insulin sensitization on pubertal progression following lifestyle intervention and/or treatment with metformin in girls with early puberty and overweight: study protocol for a randomized, placebo-controlled trial

Lasse Gliemann, Ajay Thankamony, Ken K. Ong, Julie Tonsgaard Kloppenborg et al.
Trials
Hypothalamic control of reproductive hormones
article

The LIFE-MET trial: effect of insulin sensitization on pubertal progression following lifestyle intervention and/or treatment with metformin in girls with early puberty and overweight: study protocol for a randomized, placebo-controlled trial

Lasse Gliemann, Ajay Thankamony, Ken K. Ong, Julie Tonsgaard Kloppenborg, Astrid Bruun Rasmussen, Rikke Beck Jensen, Jesper Johannesen, Ann-Margrethe Rønholt Christensen, Annette Mouritsen, Grith Lærkholm, Line Anker Bang Thybo
article en

Abstract

No abstract available for this paper.
TrialsVol. 26(1)
University of Copenhagen (DK), Steno Diabetes Centers (DK), University of Cambridge (GB), Aalborg University Hospital (DK), Aarhus University Hospital (DK), Cambridge University Hospitals NHS Foundation Trust (GB), Gentofte Hospital (DK), Zealand University Hospital (DK), University College Copenhagen (DK), Nutrition Sciences (Belgium) (BE), Lillebaelt Hospital (DK), MRC Epidemiology Unit (GB)
Gentofte Hospital
Openalex Percentile: Top 54%
Hypothalamic control of reproductive hormones
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The LIFE-MET trial: effect of insulin sensitization on pubertal progression following lifestyle intervention and/or treatment with metformin in girls with early puberty and overweight: study protocol for a randomized, placebo-controlled trial — Lasse Gliemann, Ajay Thankamony, et al. · Trials (2025) | TGRS Research Map | TGRS