Deferoxamine improves femoral trochlear dysplasia following patellar dislocation through HIF-1α/VEGF-mediated angiogenesis-osteogenesis coupling
HIF-1α/VEGF-mediated angiogenesis-osteogenesis coupling plays an important role in trochlear dysplasia following PD. Intra-articular injections of DFO improve trochlear morphology, bone microstructure, and reduce cartilage degeneration by stabilizing HIF-1α to upregulate VEGF and osteogenic markers (RUNX2, ALP, OPN).
Authors
- Zhengyi Ni
- Chenyue Xu (ORCID: https://orcid.org/0000-0002-8484-3181)
- Zhigang Zhao (ORCID: https://orcid.org/0000-0002-5252-4813)
- Huijun Kang
- Ting Fu (ORCID: https://orcid.org/0000-0002-2330-6665)
- Yao Li (ORCID: https://orcid.org/0009-0007-2980-5274)
- Fei Wang (ORCID: https://orcid.org/0000-0002-4812-9394)
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Hebei General Hospital (CN)
- First Hospital of Shijiazhuang (CN)
- China People's Police University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s13018-025-06432-5
- Primary Topic
- Lower Extremity Biomechanics and Pathologies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province
- Hebei Medical University