A case of folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy regimen associated neurotoxicity and review of literature
FOLFOX (folinic acid, 5-fluorouracil, and oxaliplatin) chemotherapy regimen is a widely used chemotherapy agent for the management of gastrointestinal malignancies. FOLFOX has been linked to various toxicities including peripheral neurotoxicity. We report a case of central neurotoxicity demonstrated clinically and radiographically within 24 h of FOLFOX administration in a patient with metastatic gastric adenocarcinoma. We further review these clinical and radiographic characteristics to help guide treatment and management of these patients.
Authors
- Naresh Mullaguri (ORCID: https://orcid.org/0000-0001-6850-3294)
- Sanjeev Sivakumar (ORCID: https://orcid.org/0000-0002-4846-4301)
- J. B. Srivastava
- Esha Kataria
Institutions
- Prisma Health (US)
- Greenville Memorial Hospital (US)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12883-025-04416-w
- Citations
- 1
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.05