Progranulin deficiency exacerbates postoperative cognitive dysfunction via RhoA-mediated axodendritic impairment in aged mice
PGRN deficiency drives POCD pathogenesis via RhoA-mediated cytoskeletal dysfunction. Therapeutic targeting of the PGRN-RhoA axis presents a novel strategy to preserve neuronal connectivity and mitigate postoperative cognitive decline in aging populations.
Authors
- Xiaofeng Lei
- Ya Yan
- Dan Wang (ORCID: https://orcid.org/0000-0002-0185-1347)
- Chun Yang (ORCID: https://orcid.org/0009-0008-1535-377X)
- Xinyu Tian (ORCID: https://orcid.org/0000-0002-6933-8021)
- Gang Wang (ORCID: https://orcid.org/0000-0001-5859-3724)
- Yvonne Lu (ORCID: https://orcid.org/0000-0002-1345-4541)
Institutions
- Soochow University (CN)
- Chongqing Maternal and Child Health Hospital (CN)
- Suzhou Municipal Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111649
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00