A case report of insulin autoimmune syndrome induced by drugs for colorectal cancer

This represents the first documented case of IAS triggered by the coadministration of oxaliplatin and omeprazole, addressing a critical knowledge gap regarding autoimmune hypoglycemia induced by the synergistic interaction of these 2 drug classes. Our findings offer novel insights into adverse drug reaction surveillance. For patients receiving chemotherapy in combination with proton pump inhibitors, this case highlights essential diagnostic considerations for identifying IAS as a rare complication - including the temporal relationship between hypoglycemic episodes and medication use, as well as the importance of insulin autoantibody testing. These observations may enhance clinical awareness of atypical hypoglycemia etiologies.