Single-cell transcriptomic analysis reveals the heterogeneity and functional characteristics of macrophage subpopulations in colon cancer
The Macrophages_SPP1 subtype may contribute to colon cancer progression through metabolic reprogramming and stromal interactions, suggesting that SPP1 and the FTL-SCARA5 axis could represent potential therapeutic targets.
Authors
- Baochun Wang (ORCID: https://orcid.org/0000-0001-6889-0204)
- Min Yi (ORCID: https://orcid.org/0000-0001-8662-6546)
- Xiao Li (ORCID: https://orcid.org/0000-0001-9785-4907)
- Jiazheng Zhao (ORCID: https://orcid.org/0000-0001-5059-1054)
- Chengcheng Wei (ORCID: https://orcid.org/0000-0002-6634-0572)
- Dayong Wang (ORCID: https://orcid.org/0000-0002-2086-1663)
Institutions
- Hainan University (CN)
- Affiliated Hospital of Taishan Medical University (CN)
- Hainan General Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1007/s12672-025-04002-z
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80