3,4‐Methylenedioxymethamphetamine (MDMA) does not induce robust psychomotor activation and 50‐kHz ultrasonic vocalisations in <i>tryptophan hydroxylase 2 (Tph2)</i> ‐deficient rats lacking serotonin in the central nervous system
MDMA does not induce a prominent increase in psychomotor activation and 50-kHz USV in Tph2-deficient rats lacking 5-HT in the central nervous system. This suggests that the robust induction of arousal and euphoria by MDMA in intact rats is not driven by the release of DA or NA, but depends on central 5-HT.
Authors
- Tianhua Wang (ORCID: https://orcid.org/0009-0008-3859-9406)
- Markus Wöhr (ORCID: https://orcid.org/0000-0001-6986-5684)
- Rainer K.W. Schwarting (ORCID: https://orcid.org/0000-0002-4686-3974)
Institutions
- Philipps University of Marburg (DE)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- KU Leuven (BE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1111/bph.70226
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Philipps-Universität Marburg
- European Commission
- Deutsche Forschungsgemeinschaft