Interleukin‐33 Promotes Interstitial Lung Disease in Idiopathic Inflammatory Myopathy Via <scp>ERK</scp> ‐Mediated Epithelial‐Mesenchymal Transition: <scp>ERK</scp> as a Potential Therapeutic Target
IL-33 promotes IIM-ILD progression by activating ERK-mediate EMT, identifying the IL-33/ERK signaling axis as a potential therapeutic target. These results provide mechanistic insight into IIM-ILD pathogenesis and support translational strategies for precision intervention.
Authors
- Jin Guo (ORCID: https://orcid.org/0000-0001-6015-8860)
- Jumei Yang
- Qiyan Su
- Wenjun Li (ORCID: https://orcid.org/0000-0001-5335-7386)
- Zhong Huang (ORCID: https://orcid.org/0000-0002-6580-3870)
- Yingyue Feng
- Sigong Zhang (ORCID: https://orcid.org/0000-0003-1565-1431)
- Hui Chai (ORCID: https://orcid.org/0009-0007-9974-3881)
- Jiarui Zhu (ORCID: https://orcid.org/0000-0001-6225-8910)
- Xi Cui (ORCID: https://orcid.org/0000-0003-0069-9985)
- Yun Lv
Institutions
- Gansu Provincial Hospital (CN)
- Gansu Provincial Cancer Hospital Gansu Provincial Academic Instiute for Medical Research (CN)
- Lanzhou University Second Hospital (CN)
- Center for Rheumatology (US)
- Gansu Provincial Center for Disease Control and Prevention (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1002/art.43453
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00