Prevalence of low-functioning alleles of folate cycle genes and their association with cardiovascular pathology and a complicated obstetric history in the population of the Arkhangelsk Region

The distribution of allelic variants of folate metabolism genes in the world’s populations varies significantly depending on ethnicity and geographical area of residence. According to a number of studies, the presence of polymorphism in folate cycle genes may be associated with various pathological conditions, including diseases of the cardiovascular system and complications of the physiological course of pregnancy. However, there are studies that do not show the presence of a relationship between the carriage of minor folate cycle gene alleles with cardiovascular pathology and a burdened obstetric history. The purpose of the study was to analyze the spread of allelic variants of folate metabolism genes, their relationship with cardiovascular pathology and complications of pregnancy. Materials and methods. The study included 2.672 people. All participants underwent real-time molecular genetic examination of folate cycle genes by PCR. The analysis of the distribution of folate cycle gene alleles in the population of the Arkhangelsk region was carried out and the presence of a correlation between the carriage of alleles with low functional activity with cardiovascular pathology and a burdened obstetric history was assessed. Results. The carriage of minor alleles of folate metabolism genes in the study sample is presented as follows: the frequency of the T allele of the MTHFR C677T gene (rs1801133) is 28.8%, the C allele of the MTHFR A1298C gene (rs1801131) is 33.1%, the G allele of the MTR A2756G gene (rs1805087) is 24.1%, the G allele The MTRR A66G gene (rs1801394) is 56.2%. There were no significant differences in the frequency of carriage of minor allelic variants of folate cycle genes between healthy volunteers and RCATT patients. Conclusion. In the studied sample, the carriage of low-functional allelic variants of genes encoding folate cycle enzymes was not associated with cardiovascular diseases and a burdened obstetric history.