EphB2 Receptor Expression in Histological Layers of Rat Hippocampus

The hippocampus is one of the main brain regions affected by major diseases such as depression, Alzheimer's disease, Parkinson's disease, and epilepsy. Different histological sub-areas of the hippocampus are reported to be affected by various pathological processes. Eph receptors are members of a family of transmembrane receptors involved in processes necessary for neuronal plasticity. Among these receptors, EphB2 plays a role in both morphological and synaptic plasticity in regulating LTP in the hippocampus. In this study, we aimed to investigate the expression intensities of the EphB2 receptor, which is essential in hippocampal processes in histological substrates in the hippocampus. In brain sections from rats, EphB2 was immunofluorescently stained, and fluorescence intensities in hippocampal areas were evaluated. According to our results, the expression levels of EphB2 receptors vary in the lower layers of the hippocampus. The dentate gyrus was the anatomical layer with the highest expression of EphB2. In all areas, higher EphB2 clustering was detected in cellular layers compared to other layers. Differences in the expression of EphB2 in different layers may be related to behavioural disorders that develop in various nervous system pathologies. Our results may be useful for future studies that will provide a better understanding of molecular pathways in morphological and synaptic plasticity.