Enhanced diagnostic yield and clinical impact of metagenomic next-generation sequencing in infective endocarditis: a continuous and prospective surgical cohort study
mNGS significantly enhances microbiological diagnosis in IE, especially in BCNE, complements traditional methods, and improves clinical decision-making. However, it requires expert interpretation to mitigate false positives.
Authors
- Oudi Chen
- Hongkun Qing
- Xuejiao Hu (ORCID: https://orcid.org/0000-0003-1471-1658)
- Xuhua Jian
- Lanxin Ye
- Fanyu Chen (ORCID: https://orcid.org/0000-0002-1102-2534)
- Weiteng Wang (ORCID: https://orcid.org/0000-0001-6480-9325)
- Lixi Gan
- Zhuang Li (ORCID: https://orcid.org/0000-0002-6938-1177)
- Qingyan Ma
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Fu Wai Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1097/js9.0000000000003954
- Primary Topic
- Infective Endocarditis Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00