Gastric Organoid-Based Ectopic and Orthotopic In Vivo CRISPR Screening for Tumor Suppressors in Gastric Cancer
In summary, we describe here a versatile model of gastric carcinogenesis that uncouples the genetics of the tumor and the host, and that faithfully recapitulates key risk factors of the malignancy.
Authors
- Agnes Hotz
- Gavin Geiger
- Zacharias Kontarakis (ORCID: https://orcid.org/0000-0001-8825-8513)
- Alexandar Tzankov (ORCID: https://orcid.org/0000-0002-1100-3819)
- Mariela Artola-Borán
- Achim Weber (ORCID: https://orcid.org/0000-0003-0073-3637)
- Peter Leary (ORCID: https://orcid.org/0000-0003-1430-6185)
- Rafaela Ferreira Cassio
- Anne Müller
- Jiazhuo He
- Biel Francas
- Flora Azizi
- G Papa
- Lydia Kirsche (ORCID: https://orcid.org/0009-0002-1826-3952)
Institutions
- University of Zurich (CH)
- University Hospital of Basel (CH)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Gastroenterology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1053/j.gastro.2025.09.009
- Citations
- 2
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 1.61