Triplet nitrene-mediated photocatalytic azidation of tertiary C(sp <sup>3</sup> )–H bonds
A photocatalytic C(sp<sup>3</sup>)-H azidation involving a triplet nitrene as a hydrogen atom abstractor is described. The key nitrene intermediate is generated through energy transfer to a sulfonyl azide, which also functions as an azide source. This method exhibits excellent selectivity for tertiary C-H bonds and is applicable to leucine-containing dipeptides.
Authors
- Hiroaki Ohno (ORCID: https://orcid.org/0000-0002-3246-4809)
- Nobuo Shimamoto (ORCID: https://orcid.org/0000-0001-7579-0084)
- Norihito Arichi (ORCID: https://orcid.org/0000-0003-3618-4959)
Institutions
- Kyoto University (JP)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1039/d5cc05587c
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00