Effects of cannabidiol on behavioral and psychological symptoms of vascular dementia: A randomized, double-blind, placebo-controlled clinical trial
CBD was well tolerated and effectively reduced BPSD in VaD without cognitive or functional impairment. These findings warrant further trials with larger samples, extended durations, and dose-optimization strategies to confirm its therapeutic potential. This study was registered at the Brazilian Clinical Trials Registry (ReBEC; ID: RBR-686kmpz, available at https://ensaiosclinicos.gov.br/rg/RBR-686kmpz).
Authors
- Rebeca Mendes de Paula Pessoa (ORCID: https://orcid.org/0000-0003-0867-1821)
- Octávio Marques Pontes‐Neto (ORCID: https://orcid.org/0000-0003-0317-843X)
- José Alexandre S. Crippa (ORCID: https://orcid.org/0000-0001-9520-6746)
- Marcos Hortes Nisihara Chagas (ORCID: https://orcid.org/0000-0003-3752-7984)
- Guilherme Riccioppo Rodrigues (ORCID: https://orcid.org/0000-0003-1475-1908)
- Antônio Waldo Zuardi (ORCID: https://orcid.org/0000-0002-0479-6670)
- Rui Martins (ORCID: https://orcid.org/0000-0002-0564-5938)
- Jaime E. C. Hallak (ORCID: https://orcid.org/0000-0002-8784-0189)
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Centro Universitário Barão de Mauá (BR)
- Hospital das Clínicas da Universidade Federal de Minas Gerais (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1177/02698811251390974
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00