Characteristics of pulmonary lymphoma on baseline 18F-FDG positron emission tomography/computed tomography and their clinical value in predicting treatment response

PPLs and SPLs demonstrate distinct albeit nonspecific PET/CT manifestations, representing preliminary yet inconclusive differentiation value. Several features, including FDG distribution patterns and lesion morphology, correlate with treatment response, but their causal relationship remains undetermined. Pleural involvement in PPL is associated with improved treatment response, while elevated baseline TBR_blood in SPL correlates with poorer metabolic remission, indicating that baseline PET/CT parameters may have predictive utility. Further validation of these findings is required.