Deoxycholic Acid and Lipoteichoic Acid cooperatively drive macrophage M2/M1 polarization via TGR5/STAT3 and TLR2/NF-κB to fuel HCC progression in obesity
DCA and LTA synergistically promote HCC progression in obesity by co-modulating the TLR2-TGR5 signaling axis in macrophages, thereby reshaping the tumor immune microenvironment.
Authors
- X Ding
- Mingxing Ding (ORCID: https://orcid.org/0000-0001-5859-5770)
- Qingyuan Jin (ORCID: https://orcid.org/0000-0001-6605-3832)
- Jian Wu (ORCID: https://orcid.org/0000-0002-2793-4810)
- Wen Zheng
Institutions
- Jinhua Academy of Agricultural Sciences (CN)
- Community Health Center (US)
- Jinhua University of Vocational Technology (CN)
Publication Details
- Journal
- Metabolism Open
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1016/j.metop.2025.100420
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00