Effect of GLP-1 agonists on testosterone levels: a systematic review and meta-analysis
GLP-1 RAs appear to elevate bioavailable testosterone and improve glycemic control, while effects on free testosterone and SHBG remain inconclusive. These findings suggest possible endocrine benefits of GLP-1 therapy; however, further well-powered studies are warranted.
Authors
- Juan Victor Nabhan Martinez (ORCID: https://orcid.org/0009-0008-0609-5799)
- Breno Cordeiro Porto (ORCID: https://orcid.org/0000-0002-4004-4089)
- Susan Orra (ORCID: https://orcid.org/0009-0002-0136-8432)
- Carlo C. Passerotti (ORCID: https://orcid.org/0000-0003-3023-6797)
- Rodrigo A. S. Sardenberg (ORCID: https://orcid.org/0000-0002-6010-1829)
- José Arnaldo Shiomi da Cruz (ORCID: https://orcid.org/0000-0003-4203-3196)
Institutions
- Universidade de São Paulo (BR)
- Yahoo (Spain) (ES)
- Universidade Nove de Julho (BR)
- Hague Institute of Private International and Foreign Law (NL)
Publication Details
- Journal
- BMC Urology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12894-025-02005-0
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00