Mycobacterium tuberculosis uses intrinsically disordered, fast evolving proteins to interact with conserved host factors
Our data point to a role of IDRs in contributing to bacterial virulence, interaction with the human host, and control of immune responses. Although this awaits experimental validation, we suggest that Mycobacterium tuberculosis also uses IDRs to sense and interact with its environment. Herein, we provide a database of bacterial IDRs, together with relevant parameters, for public use.
Authors
- Federica Arrigoni (ORCID: https://orcid.org/0000-0003-0691-7517)
- Rachele Cagliani (ORCID: https://orcid.org/0000-0003-2670-3532)
- Manuela Sironi (ORCID: https://orcid.org/0000-0002-2267-5266)
- Luca De Gioia (ORCID: https://orcid.org/0000-0003-2873-3663)
- Diego Forni (ORCID: https://orcid.org/0000-0001-9291-5352)
Institutions
- IRCCS Eugenio Medea (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Genome biology
- Published
- 2025-11-23
- DOI
- https://doi.org/10.1186/s13059-025-03854-6
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Ministero della Salute