Spinal dorsal horn IGF1 mediates the preventive effect of electroacupuncture on cisplatin-induced peripheral neuropathy via neuronal IGF1R in mice
Spinal dorsal horn IGF1 contributes to the preventive effect of EA treatment against cisplatin-induced peripheral neuropathy through neuronal IGF1R signaling in mice. The enhanced neuronal IGF1/IGF1R signaling in the spinal cord presents a potential strategy for CIPN prevention.
Authors
- Ruofan Zhang (ORCID: https://orcid.org/0000-0002-2295-6009)
- Qi‐Liang Mao‐Ying (ORCID: https://orcid.org/0000-0003-0303-0371)
- Xiaochen Li (ORCID: https://orcid.org/0000-0002-2161-6168)
- Yan-Qing Wang
- Yu‐Xia Chu
- Ya–Chen Yang
- Hui Chen (ORCID: https://orcid.org/0000-0002-2574-8256)
- Chia-Chun Fu
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Shanghai Research Center for Acupuncture and Meridians (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s13020-025-01256-1
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China