Adipose-derived mesenchymal stem cell therapy modulates mitochondrial function to attenuate acetaminophen-induced liver injury by DDIT4/PGC-1α axis
In summary, this study indicates the potential role of stem cell therapy in modulating mitochondrial function and highlights the role of activation the DDIT4/PGC-1α pathway in protecting hepatic mitochondria to alleviate AILI. This study provides a new mechanistic perspective for stem cell therapy in the treatment of AILI and potential targets for clinical drug development.
Authors
- Caixia Xia (ORCID: https://orcid.org/0000-0001-6917-5237)
- Jinjin Qi
- Guohua Lou (ORCID: https://orcid.org/0000-0002-2829-3429)
- Shaomian Yao (ORCID: https://orcid.org/0000-0002-3697-6043)
- Yanning Liu (ORCID: https://orcid.org/0000-0002-0554-6622)
- Yelei Cen (ORCID: https://orcid.org/0000-0002-9083-3545)
- Xinyu Weng (ORCID: https://orcid.org/0000-0002-7620-0813)
- Min Zheng (ORCID: https://orcid.org/0000-0001-6159-9879)
Institutions
- National Centre for Infectious Diseases (SG)
- South China Institute of Collaborative Innovation (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s13287-025-04815-3
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00