SIRT5-mediated regulation of BMP2 succinylation enhances osteogenic differentiation of BMSCs and promotes tibial fracture healing
SIRT5 promotes osteogenic differentiation of BMSCs and enhances fracture healing by modulating BMP2 succinylation. These findings suggest that SIRT5 could be a potential therapeutic target for the treatment of bone fractures and other skeletal disorders.
Authors
- Buhan Liu (ORCID: https://orcid.org/0000-0002-6359-3240)
- Yue An
- Hong‐Feng Gu (ORCID: https://orcid.org/0000-0002-4062-7057)
Institutions
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s13287-025-04808-2
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00