Mechanistic insights into GPAA1-mediated cold tumor phenotype and immune evasion in colorectal cancer: integrative multi-omics analysis and experimental validation

GPAA1 drives CRC progression via genomic instability and immunosuppression, serving as a prognostic biomarker and potential therapeutic target.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-11-24
DOI
https://doi.org/10.3389/fonc.2025.1701368
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00
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article

Mechanistic insights into GPAA1-mediated cold tumor phenotype and immune evasion in colorectal cancer: integrative multi-omics analysis and experimental validation

Yichen Cai, Hancheng Fan, Tao Zhu, Jia Zhu
Frontiers in Oncology
Cancer Immunotherapy and Biomarkers
article

Mechanistic insights into GPAA1-mediated cold tumor phenotype and immune evasion in colorectal cancer: integrative multi-omics analysis and experimental validation

Yichen Cai, Hancheng Fan, Tao Zhu, Jia Zhu
article en

Abstract

GPAA1 drives CRC progression via genomic instability and immunosuppression, serving as a prognostic biomarker and potential therapeutic target.

Frontiers in OncologyVol. 15
Sir Run Run Shaw Hospital (CN)
Openalex Percentile: Top 51%
Cancer Immunotherapy and Biomarkers
DOIOpen Access PDFOpenAlex
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Mechanistic insights into GPAA1-mediated cold tumor phenotype and immune evasion in colorectal cancer: integrative multi-omics analysis and experimental validation — Yichen Cai, Hancheng Fan, et al. · Frontiers in Oncology (2025) | TGRS Research Map | TGRS