Caprine herpes virus-1 reduces cell viability and enhances chemosensitivity in breast cancer cells
These findings highlight CpHV-1 as a promising oncolytic agent capable of targeting multiple breast cancer subtypes. Its ability to significantly reduce viability, impair long-term proliferation, and induce apoptosis, together with its synergistic activity when combined with FDA-approved targeted therapies and its limited toxicity in normal cells, supports further investigation of CpHV-1 for breast cancer treatment.
Authors
- Francesco Pagano (ORCID: https://orcid.org/0000-0002-1472-1787)
- Luigi Alfano (ORCID: https://orcid.org/0000-0002-4516-9956)
- Michelino De Laurentiis (ORCID: https://orcid.org/0000-0001-9009-1572)
- Carmelina Antonella Iannuzzi (ORCID: https://orcid.org/0000-0002-4445-9687)
- Roberto Ciarcia (ORCID: https://orcid.org/0000-0003-4121-4905)
- Iris Maria Forte (ORCID: https://orcid.org/0000-0001-9490-5844)
- Sara Damiano (ORCID: https://orcid.org/0000-0001-7798-7710)
- Serena Montagnaro (ORCID: https://orcid.org/0000-0001-5569-8774)
- Stefania Cocco (ORCID: https://orcid.org/0000-0003-3169-1580)
- Alessandra Calabrese (ORCID: https://orcid.org/0000-0002-2814-5207)
- Claudia von Arx (ORCID: https://orcid.org/0000-0001-6078-4271)
- Matteo Tomeo (ORCID: https://orcid.org/0000-0002-7160-1589)
- Antonio Giordano (ORCID: https://orcid.org/0000-0002-7760-9717)
- Anna Sfera
- R. Carmerlingo
Institutions
- University of Siena (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Scuola Superiore Meridionale (IT)
- University of Naples Federico II (IT)
- Temple University (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fonc.2025.1676296
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00