Well-differentiated HPV-independent gastric-type adenocarcinoma of the cervix: a case report and literature review

Highly differentiated HPV-independent cervical gastric-type adenocarcinoma is insidious in onset and progresses rapidly. Clinically, it often presents with abnormal vaginal discharge or bleeding, and deep biopsy or cervical conization is often required for diagnosis. Pathologically, it is characterized by randomly distributed, highly differentiated tumoral glands, which often invade deep into the uterine wall, extending beyond 2/3 of the cervical wall. It also shows positive expression of gastric-type markers such as MUC6, Mucin 5AC, and HIK1083. Imaging examination revealed the size of the lesion, depth of infiltration, the invasion of adjacent organs, and lymph node metastasis, which is beneficial for differential diagnosis, clinical staging, and the development of a treatment plan.