Temporal and subgroup disparities in mediation effects on cardiovascular outcomes with liraglutide and semaglutide: a post-hoc analysis of LEADER and SUSTAIN-6 trials
The HbA<sub>1c</sub>-mediated effects of liraglutide and semaglutide varied over time and across patient subgroups. HbA<sub>1c</sub> consistently explained a larger proportion of mediation compared to UACR and SBP, with patterns suggesting that mediation through HbA<sub>1c</sub> may differ by underlying risk factors.
Authors
- Shihchen Kuo (ORCID: https://orcid.org/0000-0001-6207-8792)
- Zi‐Yang Peng
- Yu‐Hsuan Lee (ORCID: https://orcid.org/0000-0001-7660-3770)
- Huang‐Tz Ou (ORCID: https://orcid.org/0000-0002-5475-7848)
Institutions
- University of Michigan (US)
- Michigan United (US)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1186/s12933-025-03007-w
- Citations
- 1
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29