Discovery and serological validation of DAMP-derived B-cell epitopes as diagnostic biomarkers for diabetic nephropathy
This study successfully identified and validated three novel DAMP-derived B-cell epitopes with significant diagnostic potential for diabetic nephropathy. The peptides exhibited high immunogenicity, strong specificity, and consistent performance in ELISA-based serological assays. These findings pave the way for the development of noninvasive, peptide-based diagnostic tools for early DN detection. Future efforts will focus on multicenter validation and integration into multiplex serological panels.
Authors
- Fuhua Zhong
- Zhuo Fang (ORCID: https://orcid.org/0000-0001-6742-7955)
- Yi Dong (ORCID: https://orcid.org/0000-0001-9898-9571)
- Chengyuan Yu (ORCID: https://orcid.org/0000-0001-8653-1512)
- Jun Zeng (ORCID: https://orcid.org/0009-0005-4031-1297)
Institutions
- Southern University of Science and Technology (CN)
- ShenZhen People’s Hospital (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.3389/fendo.2025.1652922
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00