Co-existence of chronic spontaneous urticaria with atopic dermatitis: clinical and immunological perspectives

CSU and AD frequently co-exist, likely due to overlapping T-cell-mediated immunopathogenic mechanisms. High total IgE and asthma comorbidity may indicate an underlying AD component in CSU patients. Recognition of this overlap is essential for appropriate therapeutic decision-making, including potential escalation to biologic agents targeting T-cell cytokine pathways.