TCF3 activates VEGFA transcription and reinforces PD-L1 expression in lung adenocarcinoma cells via NF-κB to attenuate the cytotoxicity of CD8 <sup>+</sup> T cells
This article reveals that the TCF3/VEGFA axis enhances the expression of PD-L1 in LUAD by activating the NF-κB signaling pathway, thereby weakening the cytotoxicity of CD8<sup>+</sup> T cells.
Authors
- Xiaoli Tan (ORCID: https://orcid.org/0000-0002-8729-3955)
- Zhixiang Xiao
- Xiaodong Lv
- Wenyu Chen (ORCID: https://orcid.org/0000-0001-8768-0042)
- Yufen Xu (ORCID: https://orcid.org/0000-0002-0858-5715)
Institutions
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
- Zhejiang Medicine (China) (CN)
Publication Details
- Journal
- Expert Review of Clinical Immunology
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1080/1744666x.2025.2585347
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00